Gut Microbiome Health Plays Role in Fighting Depression During Pandemic



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There is a growing body of evidence linking depression to microbiome health. A new study proposes focusing on the microbiome may help alleviate some of the symptoms of depression associated with the COVID-19 pandemic.

Source: University Hospitals Cleveland Medical Center

Researchers from Case Western Reserve University, University Hospitals Cleveland Medical Center (UH), BIOHM Health LLC, and the Louis Stokes Cleveland VA Medical Center have published a paper in the Frontiers of Nutrition, proposing a hypothesis and theory about a microbiome-driven approach to combating depression during the COVID-19 pandemic.

In their paper, Mahmoud A. Ghannoum, Ph.D., FAAM, FIDSA, and colleagues, write that significant stressors brought about and exacerbated by COVID-19 are associated with startling surges in mental health illnesses, specifically those related to depressive disorders.

Within a one-month period at the beginning of the COVID-19 pandemic, the researchers write that there was a reported 34.1 percent increase in prescriptions for anti-anxiety medications, an 18.6 percent increase in antidepressant prescriptions, and a 14.8 percent increase in common anti-insomnia drugs including prescribed anti-insomnia medications in the United States.

“During such a short period of time, this steep rise hints at the magnitude of COVID-19’s immediate and widespread effect on mental health,” said Dr. Ghannoum, director of the Center for Medical Mycology at UH and professor of dermatology and pathology at the Case Western Reserve University School of Medicine.

In their paper, published Aug. 24, Dr. Ghannoum and colleagues examined the current literature surrounding the microbiome and gut-brain axis to advance a potential complementary approach to address depression and depressive disorders that have increased during the COVID-19 pandemic.

“The impact of the human gut microbiome on emotional health is a newly emerging field,” said Dr. Ghannoum. “While more research needs to be conducted, the current evidence is extremely promising and suggests at least part of the answer to understanding depression in more depth may lie within the microbiome.”

The microbiome is defined as the collective genomes of the microbes (composed of bacteria, fungi, protozoa and viruses) that live inside and on the human body, but primarily in the human gut. Scientists are learning that these microbes play a significant role in health and disease.

Studies also suggest the microbiome impacts our brain and emotions. The gut microbiome and the brain communicate with each other through neural, inflammatory, and hormonal signaling pathways. As a result of the two-way interaction between the gut microbiome and the brain, each can send messages that impact the other.

Dr. Ghannoum and colleagues propose that a microbiome-based holistic approach, which involves carefully annotating the microbiome and potential modification through diet, probiotics, and lifestyle changes, may address depression.

“Despite the toll that depression has on both individuals and society, understanding and effectively treating depressive disorders is difficult,” Dr. Ghannoum said. “Current research addressing the diagnosis and treatment of depression and mood disorders is ongoing, but needs more time to develop the complexities involved how to treat them.”

He said some studies have shed light on the potential correlation between COVID infection and microbiome disturbance, but have limitations that require further investigations with larger sample sizes to approximate the general population.

However, the researchers found more evidence supporting the gut-brain link a